Dr. Mackay on India's acute encephalitis syndrome

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Source: crofsblogs.typepad.com --- Sunday, July 14, 2013
Via his blog Virology Down Under, Dr. Ian Mackay writes about? India's Acute Encephalitis Syndrome (AcEnSy) . Excerpt: The NYT article notes that the US CDC is collaborating on a project to seek a cause(s). Hopefully that will yield solid leads before another year passes and more children succumb. Beyond financial issues underpinning PCR-based diagnostic testing, it is hard for me to understand why this has not been tackled in a collaborative manner, earlier. Obtaining basic knowledge ("what is causing this disease?") may not be a sexy topic for grant funding, but it is the cornerstone on which a solid public health foundation is built.? To know and understand what bug (I mean virus, but I include bacteria!) you face you could:? ? Screen for known bugs using existing PCR assays? ? If unsuccessful, hunt using next generation sequencing technology? ? Characterise the culprit if it's new or if it's a variant of something already known - get the genome, feed that information back into assay design to make sure your assay works properly and that the first hit wasn't luck, design a second and third assay to different regions of the genome to provide detection redundancy, continue searching to find all the strains? ? Create serological assays to determine nature of infection? ? Incorporate the new target into the existing diagnostic menu - and keep revising that menu? ? Publish the results, update your peers, modify your patient managem ...

Source: http://crofsblogs.typepad.com/h5n1/2013/07/dr-mackay-on-indias-acute-encephalitis-syndrome.html

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